Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdkn1b  cyclin dependent kinase inhibitor 1B   (Synonyms: p27, p27Kip1)
Results	Reference
1	J:182789 Abe K, Naruse C, Kato T, Nishiuchi T, Saitou M, Asano M, Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice. Biol Reprod. 2011 Nov;85(5):1013-24
1	J:214083 Boucherat O, Nadeau V, Berube-Simard FA, Charron J, Jeannotte L, Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development. 2014 Aug;141(16):3197-211
1	J:154462 Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, Lefebvre PP, Malgrange B, Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti. Dev Biol. 2009 Nov 15;335(2):327-39
1	J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
1	J:334017 Bunce C, Barske L, Zhang G, Capel B, Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse. Development. 2023 Mar 1;150(5):dev201060
1	J:228026 Capecchi MR, Pozner A, ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 2015;6:8763
1	J:116542 Georgia S, Bhushan A, p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov;55(11):2950-6
1	J:151321 Glickstein SB, Monaghan JA, Koeller HB, Jones TK, Ross ME, Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex. J Neurosci. 2009 Jul 29;29(30):9614-24
1	J:127074 Glickstein SB, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, Ross ME, Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007 Nov;134(22):4083-93
1	J:189076 Godin JD, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, Purnelle A, Raineteau O, Campbell K, Fero M, Moonen G, Malgrange B, Chariot A, Metin C, Besson A, Nguyen L, p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration. Dev Cell. 2012 Oct 16;23(4):729-44
1	J:77351 Goudreau G, Petrou P, Reneker LW, Graw J, Loster J, Gruss P, Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
1*	J:67807 Gritli-Linde A, Nilsson J, Bohlooly-Y M, Heby O, Linde A, Nuclear translocation of antizyme and expression of ornithine decarboxylase and antizyme are developmentally regulated. Dev Dyn. 2001 Mar;220(3):259-75
1	J:117093 Gui H, Li S, Matise MP, A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol. 2007 Jan 1;301(1):14-26
1*	J:231673 Gustin SE, Hogg K, Stringer JM, Rastetter RH, Pelosi E, Miles DC, Sinclair AH, Wilhelm D, Western PS, WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary. Dev Biol. 2016 Apr 15;412(2):250-60
1	J:203642 Hufnagel RB, Riesenberg AN, Quinn M, Brzezinski JA 4th, Glaser T, Brown NL, Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013 May;54:108-20
1	J:229246 Huh SH, Warchol ME, Ornitz DM, Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife. 2015;4
1*	J:168656 Ikeda Y, Matsunaga Y, Takiguchi M, Ikeda MA, Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):64-71
1	J:135191 Ishimura R, Martin GR, Ackerman SL, Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J Neurosci. 2008 May 7;28(19):4938-48
1	J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1	J:196835 Kerr CL, Huang J, Williams T, West-Mays JA, Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation. Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3316-30
1	J:123924 Kim TH, Goodman J, Anderson KV, Niswander L, Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell. 2007 Jul;13(1):87-102
1	J:79489 Knoepfler PS, Cheng PF, Eisenman RN, N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002 Oct 15;16(20):2699-712
1	J:192860 Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L, 14-3-3epsilon plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol. 2012 Dec;32(24):5089-102
1	J:272393 Lavado A, Park JY, Pare J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X, The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018 Dec 3;47(5):576-591.e8
1	J:110600 Le TT, Wroblewski E, Patel S, Riesenberg AN, Brown NL, Math5 is required for both early retinal neuron differentiation and cell cycle progression. Dev Biol. 2006 Jul 15;295(2):764-78
1	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
1	J:310819 Makrides N, Panayiotou E, Fanis P, Karaiskos C, Lapathitis G, Malas S, Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain. Front Mol Neurosci. 2018;11:152
1	J:279209 Murata J, Ohtsuka T, Tokunaga A, Nishiike S, Inohara H, Okano H, Kageyama R, Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1. J Neurosci Res. 2009 Dec;87(16):3521-34
1	J:226669 Ono K, Kita T, Sato S, O'Neill P, Mak SS, Paschaki M, Ito M, Gotoh N, Kawakami K, Sasai Y, Ladher RK, FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation. PLoS Genet. 2014 Jan;10(1):e1004118
1	J:160534 Ono Y, Nakatani T, Minaki Y, Kumai M, The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells. Development. 2010 Jun;137(11):1897-906
1	J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1	J:138714 Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL, Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008 Sep 1;321(1):111-22
1	J:168563 Shi Y, Liu JP, Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord. J Neurosci. 2011 Jan 19;31(3):883-93
1	J:275391 Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S, Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death. Hum Mol Genet. 2019 Jun 1;28(11):1822-1836
1	J:124011 Spella M, Britz O, Kotantaki P, Lygerou Z, Nishitani H, Ramsay RG, Flordellis C, Guillemot F, Mantamadiotis T, Taraviras S, Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle. Neuroscience. 2007 Jun 29;147(2):373-87
1	J:155359 Stuebner S, Faus-Kessler T, Fischer T, Wurst W, Prakash N, Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Dev Dyn. 2010 Jan;239(1):246-60
1	J:299728 Travisano SI, Oliveira VL, Prados B, Grego-Bessa J, Pineiro-Sabaris R, Bou V, Gomez MJ, Sanchez-Cabo F, MacGrogan D, de la Pompa JL, Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade. Elife. 2019 Dec 4;8:e49977
1	J:188110 Virolainen SM, Achim K, Peltopuro P, Salminen M, Partanen J, Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development. 2012 Oct;139(20):3795-805
1	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
1*	J:136711 Zhao H, Yang T, Madakashira BP, Thiels CA, Bechtle CA, Garcia CM, Zhang H, Yu K, Ornitz DM, Beebe DC, Robinson ML, Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008 Jun 15;318(2):276-88
1	J:190452 Zou C, Levine EM, Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. PLoS Genet. 2012 Sep;8(9):e1002924